The Ojibwe member tribes of the Great Lakes Indian Fish and Wildlife Commission (GLIFWC) depend on animal and plant relatives to meet spiritual, cultural, medicinal, subsistence, and economic needs. Climate change may affect the ability of tribal members to continue exercising their off-reservation treaty rights to hunt, fish, and gather these beings. We used the NatureServe Climate Change Vulnerability Index (CCVI) to assess the vulnerability of 66 beings of tribal interest to climate change. We also conducted Traditional Ecological Knowledge (TEK) interviews and reviewed previously gathered TEK to identify beings of concern and record changes experienced within the cultural memory. We used information from interviews as well as input from regional scientists familiar with each being to assess vulnerability. We found that manoomin/northern wild rice (Zizania palustris), which is integral to Ojibwe culture and already declining in population in the Ceded Territories, was the most vulnerable being. Swimmers were the most vulnerable category of beings, with odoonibiins/tullibee (Coregonus artedii) as the most vulnerable. Climate change impacts on culturally important beings were reported by TEK interviewees across the Ceded Territories, and Ojibwe people are so intertwined with some of these beings that they fear a loss of identity as these beings disappear from the landscape. We also found that the combination of SEK (Scientific Ecological Knowledge) and TEK broadened our understanding of climate change impacts on these beings. Knowledge gained in this assessment will be useful for Tribal and non-Tribal resource managers, educators, climate change adaptation practitioners, and all who believe we are responsible for caring for those beings who take care of us.